The moving stories of ten remarkable women who transformed science, and changed the world. These scientists overcame significant obstacles, often simply because they were women their science and their lives were driven by personal tragedies and shaped by seismic world events. Some were rewarded with the Nobel Prize for their pioneering achievements - Madame Curie, twice - others were not and, even if they had, many are not household names. Despite living during periods when the contribution of women was disregarded, if not ignored, these resilient women persevered with their research, whether creating life-saving drugs or expanding our knowledge of the cosmos. By daring to ask 'How?' and 'Why?' and persevering against the odds, each of these women, in a variety of ways, has made the world a better place.